Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Orc4
Flybase description The gene Origin recognition complex subunit 4 is referred to in FlyBase by the symbol Dmel\Orc4 (CG2917, FBgn0023181).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -13.7886 -11.6677 -15.319791 -19.9093 -21.733319 -18.8612 -21.19102 -19.287432
    Affimetrix absolute value 4.624 4.088 4.247 4.097 4.334 4.386 4.202 3.984
    Affymetric present call in "x" number of chips 2 3 0 0 1 2 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA binding; nucleoside-triphosphatase activity; ATP binding.
There is experimental evidence that it is involved in the biological process: DNA-dependent DNA replication initiation.
4 alleles are reported.
The phenotype of these alleles is annotated with: mesothoracic tergum.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, core; Origin recognition complex, subunit 4.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.