Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name wit
Flybase description The gene wishful thinking is referred to in FlyBase by the symbol Dmel\wit (CG10776, FBgn0024179).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.3097 -1.5997 -1.895691 -4.5977 -5.558111 -5.0583 -10.22088 -4.133324
    Affimetrix absolute value 7.245 6.967 7.406 6.207 6.404 6.239 5.218 6.398
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: transforming growth factor beta receptor activity, type II.
There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; lateral inhibition; neuromuscular junction development.
36 alleles are reported.
The phenotypes of these alleles are annotated with: wing vein L5; posterior crossvein; NMJ bouton; bouton; chaeta; neuromuscular junction; embryonic/larval neuromuscular junction; postsynaptic membrane; synapse; embryonic/larval muscle system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase-like domain; TGF-beta receptor/activin receptor, type I/II.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed during early pupal stages.