Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name gbb
Flybase description The gene glass bottom boat is referred to in FlyBase by the symbol Dmel\gbb (CG5562, FBgn0024234).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.4735 -1.2918 -2.189044 -2.1336 -3.265802 -3.0433 -1.30021 -1.804814
    Affimetrix absolute value 8.966 7.264 7.058 7.318 7.104 7.02 8.18 7.396
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: transforming growth factor beta receptor binding.
There is experimental evidence that it is involved in the biological process: neuromuscular synaptic transmission; regulation of neurotransmitter secretion; positive regulation of muscle organ development; ovarian follicle cell development; imaginal disc-derived wing vein morphogenesis; imaginal disc-derived wing vein specification; neuromuscular junction development; wing disc pattern formation.
27 alleles are reported.
The phenotypes of these alleles are annotated with 47 unique terms, many of which group under: adult segment; organ system subdivision; organ system; thoracic segment; synapse; external compound sense organ; imaginal precursor; integumentary plate; integumentary specialisation; peripheral nervous system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Transforming growth factor beta, conserved site; Transforming growth factor-beta, C-terminal; Transforming growth factor-beta, N-terminal; Transforming growth factor-beta-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.