Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name E2f2
Flybase description The gene E2F transcription factor 2 is referred to in FlyBase by the symbol Dmel\E2f2 (CG1071, FBgn0024371).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.819 -2.3112 -2.953065 -2.7431 -3.651941 -2.9271 -2.14253 -3.459795
    Affimetrix absolute value 7.549 6.42 6.615 6.933 6.893 7.013 7.463 6.473
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: oocyte anterior/posterior axis specification; negative regulation of transcription from RNA polymerase II promoter; negative regulation of DNA replication; DNA endoreduplication; oocyte dorsal/ventral axis specification.
25 alleles are reported.
The phenotypes of these alleles are annotated with: chorion; eye; follicle cell; ommatidium.
It has one annotated transcript and one annotated polypeptide.
Protein features are: E2F Family; Transcription factor E2F/dimerisation partner (TDP); Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.