Flygut: an atlas of the Drosophila adult midgut

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Gene name Top3beta
Flybase description The gene Topoisomerase 3β is referred to in FlyBase by the symbol Dmel\Top3β (CG3458, FBgn0026015).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -9.0438 -4.8363 -7.088179 -8.6052 -10.841572 -9.862 -11.81375 -8.972001
    Affimetrix absolute value 5.234 5.347 5.364 5.294 5.331 5.276 5.001 5.084
    Affymetric present call in "x" number of chips 3 3 1 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: DNA topoisomerase activity; endodeoxyribonuclease activity.
There is experimental evidence that it is involved in the biological process: DNA catabolic process, endonucleolytic.
15 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: DNA topoisomerase, type IA; DNA topoisomerase, type IA, DNA-binding; DNA topoisomerase, type IA, active site; DNA topoisomerase, type IA, central; DNA topoisomerase, type IA, central region, subdomain 1; DNA topoisomerase, type IA, central region, subdomain 2; DNA topoisomerase, type IA, core domain; DNA topoisomerase, type IA, domain 2; Toprim domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.