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|Flybase description||The gene Rho-kinase is referred to in FlyBase by the symbol Dmel\rok (CG9774, FBgn0026181).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: GTPase binding; protein binding; protein serine/threonine kinase activity.
There is experimental evidence for 26 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; localization; ovarian nurse cell to oocyte transport; multicellular organism reproduction; cell cycle; regulation of developmental process; establishment of planar polarity; regulation of cellular component organization; gamete generation.
23 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; organ system subdivision; adult segment; portion of tissue; non-connected developing system; epithelial cell; nucleus; external compound sense organ; embryonic foregut; thoracic segment.
It has one annotated transcript and one annotated polypeptide.
Protein features are: AGC-kinase, C-terminal; Pleckstrin homology domain; Pleckstrin homology-type; Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, C-terminal; Protein kinase, catalytic domain; Protein kinase-like domain; Rho Binding; Rho-associated coiled-coil containing protein kinase; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.