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|Flybase description||The gene TGF-β activated kinase 1 is referred to in FlyBase by the symbol Dmel\Tak1 (CG18492, FBgn0026323).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: JUN kinase kinase kinase activity.
There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; immune system process; sensory organ development; system development; cellular response to molecule of bacterial origin; immune response; programmed cell death; ommatidial rotation; post-embryonic organ morphogenesis; defense response to bacterium; embryonic development via the syncytial blastoderm.
29 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; external compound sense organ; organ system subdivision; peripheral nervous system; acellular anatomical structure; imaginal precursor; cephalopharyngeal skeleton; proteinaceous extracellular matrix; extracellular matrix part; adult segment.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Serine/threonine-protein kinase, active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages.