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|Flybase description||The gene Sak kinase is referred to in FlyBase by the symbol Dmel\SAK (CG7186, FBgn0026371).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity.
There is experimental evidence that it is involved in the biological process: centrosome organization; sperm axoneme assembly; mitotic spindle organization; centriole replication; centrosome duplication; regulation of centriole replication.
12 alleles are reported.
The phenotypes of these alleles are annotated with: centriole; ventral nerve cord; presumptive embryonic/larval peripheral nervous system; spermatid; centrosome; longitudinal connective; spermatid axoneme; spermatocyte; spermatozoon.
It has one annotated transcript and one annotated polypeptide.
Protein features are: POLO box duplicated domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase-like domain; Tyrosine-protein kinase, active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.