Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Axn
Flybase description The gene Axin is referred to in FlyBase by the symbol Dmel\Axn (CG7926, FBgn0026597).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -8.3525 -4.2956 -7.333517 -7.0652 -9.19754 -7.8082 -9.65222 -10.489446
    Affimetrix absolute value 5.346 5.524 5.334 5.572 5.578 5.599 5.329 4.912
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: beta-catenin binding; protein kinase binding.
There is experimental evidence that it is involved in the biological process: imaginal disc pattern formation; eye-antennal disc morphogenesis; somatic stem cell maintenance; negative regulation of Wnt receptor signaling pathway; oogenesis; imaginal disc-derived wing morphogenesis; Wnt receptor signaling pathway; phagocytosis, engulfment.
40 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system; adult segment; organ system subdivision; thoracic segment; portion of tissue; acellular anatomical structure; tracheal system; indirect flight muscle; adult; external compound sense organ.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Axin beta-catenin binding; DIX; Regulator of G protein signalling; Regulator of G protein signalling superfamily; Regulator of G-protein signaling, domain 1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.