Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Ack
Flybase description The gene Ack is referred to in FlyBase by the symbol Dmel\Ack (CG14992, FBgn0028484).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.8598 -3.4959 -6.33634 -6.8024 -9.623451 -7.395 -3.68189 -7.140384
    Affimetrix absolute value 6.896 5.826 5.517 5.661 5.502 5.73 6.724 5.414
    Affymetric present call in "x" number of chips 3 3 3 2 2 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: SH2 domain binding; protein tyrosine kinase activity.
There is experimental evidence that it is involved in the biological process: peptidyl-tyrosine phosphorylation; protein phosphorylation.
10 alleles are reported.
The phenotype of these alleles is annotated with: mesothoracic tergum.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Src homology-3 domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes.