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|Flybase description||The gene lethal with a checkpoint kinase is referred to in FlyBase by the symbol Dmel\lack (CG4943, FBgn0029006).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: decapentaplegic receptor signaling pathway; transforming growth factor beta receptor signaling pathway; embryonic hindgut morphogenesis; embryonic development via the syncytial blastoderm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of growth.
11 alleles are reported.
The phenotypes of these alleles are annotated with: leg; mesothoracic tergum; wing.
It has one annotated transcript and one annotated polypeptide.
Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; HECT; WW/Rsp5/WWP.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.