Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name lack
Flybase description The gene lethal with a checkpoint kinase is referred to in FlyBase by the symbol Dmel\lack (CG4943, FBgn0029006).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.8419 -1.6547 -2.686499 0.3882 -4.142895 -2.0094 -3.68396 -3.516267
    Affimetrix absolute value 6.136 6.893 6.841 8.458 6.794 7.555 6.73 6.582
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: decapentaplegic receptor signaling pathway; transforming growth factor beta receptor signaling pathway; embryonic hindgut morphogenesis; embryonic development via the syncytial blastoderm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; regulation of growth.
11 alleles are reported.
The phenotypes of these alleles are annotated with: leg; mesothoracic tergum; wing.
It has one annotated transcript and one annotated polypeptide.
Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; HECT; WW/Rsp5/WWP.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.