Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Dok
Flybase description The gene Downstream of kinase is referred to in FlyBase by the symbol Dmel\Dok (CG2079, FBgn0029944).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.1143 -3.2717 -3.940992 -3.9741 -7.317721 -5.1674 -2.29984 -5.171434
    Affimetrix absolute value 6.374 5.92 6.224 6.429 5.918 6.206 7.377 5.877
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: insulin receptor binding.
There is experimental evidence that it is involved in the biological process: dorsal closure, elongation of leading edge cells; dorsal closure; stress-activated protein kinase signaling cascade; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis.
12 alleles are reported.
The phenotypes of these alleles are annotated with: orbital bristle; interommatidial bristle; chaeta; heart primordium; wing; thorax.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Insulin receptor substrate-1, PTB; Pleckstrin homology domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.