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|Flybase description||The gene Downstream of kinase is referred to in FlyBase by the symbol Dmel\Dok (CG2079, FBgn0029944).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: insulin receptor binding.
There is experimental evidence that it is involved in the biological process: dorsal closure, elongation of leading edge cells; dorsal closure; stress-activated protein kinase signaling cascade; imaginal disc fusion, thorax closure; imaginal disc-derived wing morphogenesis.
12 alleles are reported.
The phenotypes of these alleles are annotated with: orbital bristle; interommatidial bristle; chaeta; heart primordium; wing; thorax.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Insulin receptor substrate-1, PTB; Pleckstrin homology domain; Pleckstrin homology-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.