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|Flybase description||The gene highwire is referred to in FlyBase by the symbol Dmel\hiw (CG32592, FBgn0030600).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; negative regulation of BMP signaling pathway; BMP signaling pathway; autophagy; regulation of synaptic growth at neuromuscular junction; synapse organization.
64 alleles are reported.
The phenotypes of these alleles are annotated with: eye; NMJ bouton; bouton; terminal button; neuromuscular junction; motor neuron; embryonic/larval neuromuscular junction; indirect flight muscle motor neuron MN4; synapse; synaptic vesicle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Anaphase-promoting complex, subunit 10/DOC domain; Filamin/ABP280 repeat-like; Galactose-binding domain-like; Immunoglobulin E-set; Immunoglobulin-like fold; PHR; Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages.