Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name hiw
Flybase description The gene highwire is referred to in FlyBase by the symbol Dmel\hiw (CG32592, FBgn0030600).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -37.1858 -3.2256 -2.872492 -4.486 -2.8963 -3.4166 -34.3479 -4.372516
    Affimetrix absolute value 3.208 5.936 6.713 6.252 7.287 6.804 3.454 6.228
    Affymetric present call in "x" number of chips 0 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; negative regulation of BMP signaling pathway; BMP signaling pathway; autophagy; regulation of synaptic growth at neuromuscular junction; synapse organization.
64 alleles are reported.
The phenotypes of these alleles are annotated with: eye; NMJ bouton; bouton; terminal button; neuromuscular junction; motor neuron; embryonic/larval neuromuscular junction; indirect flight muscle motor neuron MN4; synapse; synaptic vesicle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Anaphase-promoting complex, subunit 10/DOC domain; Filamin/ABP280 repeat-like; Galactose-binding domain-like; Immunoglobulin E-set; Immunoglobulin-like fold; PHR; Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 06-24 hour embryonic stages, at stages throughout the pupal period, in adult male stages.