Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name HERC2
Flybase description The gene HERC2 is referred to in FlyBase by the symbol Dmel\HERC2 (CG11734, FBgn0031107).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -14.0264 -9.3519 -15.991055 -12.8329 -32.171888 -19.7406 -16.53981 -25.801424
    Affimetrix absolute value 4.614 4.422 4.21 4.736 3.833 4.282 4.649 3.744
    Affymetric present call in "x" number of chips 2 1 0 1 2 2 2 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: ubiquitin-protein ligase activity; guanyl-nucleotide exchange factor activity.
An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: protein ubiquitination.
2 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Anaphase-promoting complex, subunit 10/DOC domain; CPH domain; CUB; Cytochrome b5; Galactose-binding domain-like; HECT; Mib-herc2; Regulator of chromosome condensation, RCC1; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Translation protein SH3-like, subgroup; UBA-like; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages.