Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Spp
Flybase description The gene Signal peptide protease is referred to in FlyBase by the symbol Dmel\Spp (CG11840, FBgn0031260).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.1677 5.5457 2.873926 1.3667 1.45064 1.2968 -1.32175 1.988992
    Affimetrix absolute value 8.627 10.053 9.638 8.825 9.272 8.932 8.17 9.161
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: aspartic endopeptidase activity, intramembrane cleaving.
There is experimental evidence that it is involved in the biological process: membrane protein proteolysis; open tracheal system development.
16 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; embryonic/larval tracheal system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Peptidase A22, presenilin signal peptide; Peptidase A22B, signal peptide peptidase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-18 hour embryonic stages, during early larval stages.