Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Npc2a
Flybase description The gene Niemann-Pick type C-2a is referred to in FlyBase by the symbol Dmel\Npc2a (CG7291, FBgn0031381).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.3448 3.5167 2.030022 2.2017 1.722692 3.7431 2.64126 2.074041
    Affimetrix absolute value 8.824 9.418 9.177 9.525 9.516 10.427 9.931 9.291
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions There is not condition-dependent expression data available for this gene.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sterol binding.
There is experimental evidence that it is involved in the biological process: sterol homeostasis; sterol transport; ecdysteroid biosynthetic process.
7 alleles are reported.
The phenotype of these alleles is annotated with: Malpighian tubule.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Immunoglobulin E-set; MD-2-related lipid-recognition.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-06 and 12-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.