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|Flybase description||The gene Hepatocyte growth factor regulated tyrosine kinase substrate is referred to in FlyBase by the symbol Dmel\Hrs (CG2903, FBgn0031450).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: metal ion binding.
There is experimental evidence that it is involved in the biological process: endocytosis; border follicle cell migration; positive regulation of Toll signaling pathway.
16 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; adult segment; thoracic segment; organelle; cytoplasmic part; adult; imaginal precursor; external compound sense organ; garland cell.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: ENTH/VHS; Ubiquitin binding protein, Hrs/VPS27; Ubiquitin interacting motif; VHS; VHS subgroup; Zinc finger, FYVE-related; Zinc finger, FYVE-type; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages.