Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Hrs
Flybase description The gene Hepatocyte growth factor regulated tyrosine kinase substrate is referred to in FlyBase by the symbol Dmel\Hrs (CG2903, FBgn0031450).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.2992 -1.2718 -1.326787 -1.4644 -2.099567 -1.9724 -3.7399 -1.70501
    Affimetrix absolute value 6.32 7.28 7.796 7.858 7.708 7.614 6.664 7.485
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: metal ion binding.
There is experimental evidence that it is involved in the biological process: endocytosis; border follicle cell migration; positive regulation of Toll signaling pathway.
16 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; adult segment; thoracic segment; organelle; cytoplasmic part; adult; imaginal precursor; external compound sense organ; garland cell.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: ENTH/VHS; Ubiquitin binding protein, Hrs/VPS27; Ubiquitin interacting motif; VHS; VHS subgroup; Zinc finger, FYVE-related; Zinc finger, FYVE-type; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages.