Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name aph-1
Flybase description The gene anterior pharynx defective 1 is referred to in FlyBase by the symbol Dmel\aph-1 (CG2855, FBgn0031458).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.4713 -1.2885 -1.810413 -1.5749 -2.235445 -1.5279 -2.21573 -1.802598
    Affimetrix absolute value 7.855 7.261 7.338 7.75 7.611 7.969 7.42 7.402
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: endopeptidase activity.
There is experimental evidence that it is involved in the biological process: Notch signaling pathway.
20 alleles are reported.
The phenotypes of these alleles are annotated with: eye; macrochaeta; tormogen cell; presumptive embryonic/larval nervous system; wing; microchaeta.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Aph-1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.