Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name SP1070
Flybase description The gene uninflatable is referred to in FlyBase by the symbol Dmel\uif (CG9138, FBgn0031879).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -57.0616 -35.8184 -45.21689 -59.8894 -69.218116 -66.7589 -60.61474 -51.451038
    Affimetrix absolute value 2.577 2.465 2.68 2.489 2.657 2.501 2.635 2.583
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: Notch binding.
There is experimental evidence that it is involved in the biological process: regulation of tube architecture, open tracheal system.
10 alleles are reported.
The phenotypes of these alleles are annotated with: cephalopharyngeal skeleton; trichogen cell; taenidium; embryonic/larval dorsal trunk; embryonic/larval tracheal system; mesothoracic tergum.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: C-type lectin; C-type lectin fold; C-type lectin-like; CUB; Coagulation factor 5/8 type, C-terminal; Complement control module; Concanavalin A-like lectin/glucanase; Concanavalin A-like lectin/glucanase, subgroup; EGF; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Galactose-binding domain-like; Growth factor, receptor; Hyalin; Low-density lipoprotein (LDL) receptor class A repeat; Low-density lipoprotein (LDL) receptor class A, conserved site; Sushi/SCR/CCP; TNFR/CD27/30/40/95 cysteine-rich region; Tyrosine-protein kinase ephrin type A/B receptor-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 12-18 embryonic stages, during late pupal stages.