Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name r2d2
Flybase description The gene r2d2 is referred to in FlyBase by the symbol Dmel\r2d2 (CG7138, FBgn0031951).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.4891 -4.2511 -5.02604 -7.1343 -8.088281 -7.4746 -8.7697 -6.800212
    Affimetrix absolute value 6.263 5.574 5.856 5.561 5.745 5.663 5.427 5.498
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: double-stranded RNA binding.
There is experimental evidence that it is involved in the biological process: production of small RNA involved in gene silencing by RNA; siRNA loading onto RISC involved in RNA interference; heterochromatin organization involved in chromatin silencing; ovarian follicle cell stalk formation; production of siRNA involved in RNA interference; defense response to virus; regulation of production of small RNA involved in gene silencing by RNA.
18 alleles are reported.
The phenotypes of these alleles are annotated with: interfollicle cell; trichogen cell; follicle cell; egg chamber.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Double-stranded RNA-binding; Double-stranded RNA-binding-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages.