Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Hand
Flybase description The gene Hand is referred to in FlyBase by the symbol Dmel\Hand (CG18144, FBgn0032209).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -16.7125 0.5612 -2.555123 -1.4084 -4.348275 -2.5786 -6.86647 -2.051867
    Affimetrix absolute value 4.348 7.871 6.825 7.897 6.656 7.204 5.772 7.21
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: larval heart development; negative regulation of apoptosis; hemopoiesis; embryonic heart tube development.
27 alleles are reported.
The phenotypes of these alleles are annotated with: lymph gland derived hemocyte; embryonic/larval pericardial cell; alary cell; embryonic/larval heart; lymph gland primordium; cardioblast; embryonic pericardial cell.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 06-24 hour embryonic stages, during early pupal stages.