Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name geminin
Flybase description The gene geminin is referred to in FlyBase by the symbol Dmel\geminin (CG3183, FBgn0033081).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.916 -2.724 -3.772223 -2.5313 -3.668772 -2.1084 -4.6375 -4.227482
    Affimetrix absolute value 6.865 6.175 6.283 7.057 6.899 7.498 6.356 6.194
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: DNA binding.
There is experimental evidence that it is involved in the biological process: negative regulation of epidermal growth factor receptor signaling pathway; endomitotic cell cycle; negative regulation of DNA replication.
10 alleles are reported.
The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: organ system; non-connected developing system; cell cycle; multicellular structure; organ system subdivision; cell cycle process; imaginal precursor; external compound sense organ; embryonic hindgut; embryonic/larval imaginal precursor.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Geminin.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-12 and 18-24 hour embryonic stages, in adult female stages.