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|Flybase description||The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: identical protein binding; bacterial cell surface binding; protein homodimerization activity; axon guidance receptor activity.
There is experimental evidence that it is involved in the biological process: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development.
126 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; organ system; multicellular structure; adult segment; peripheral nervous system; embryonic/larval hemocoel; cell part; non-connected developing system; adult; axon.
It has 74 annotated transcripts and 74 annotated polypeptides.
Protein features are: Down syndrome cell adhesion molecule, C-terminal; Fibronectin type III domain; Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.