Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Dscam
Flybase description The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -26.8011 -11.5019 -14.433175 -23.1044 -27.740781 -32.7312 -27.96789 -15.320077
    Affimetrix absolute value 3.671 4.146 4.38 3.866 4.047 3.573 3.751 4.344
    Affymetric present call in "x" number of chips 0 3 2 1 1 0 0 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: identical protein binding; bacterial cell surface binding; protein homodimerization activity; axon guidance receptor activity.
There is experimental evidence that it is involved in the biological process: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development.
126 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; organ system; multicellular structure; adult segment; peripheral nervous system; embryonic/larval hemocoel; cell part; non-connected developing system; adult; axon.
It has 74 annotated transcripts and 74 annotated polypeptides.
Protein features are: Down syndrome cell adhesion molecule, C-terminal; Fibronectin type III domain; Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages.