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|Flybase description||The gene Autophagy-specific gene 7 is referred to in FlyBase by the symbol Dmel\Atg7 (CG5489, FBgn0034366).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity; nucleotide binding.
There is experimental evidence that it is involved in the biological process: determination of adult lifespan; macroautophagy; regulation of defense response to virus; regulation of autophagy; autophagy; larval midgut cell programmed cell death.
11 alleles are reported.
The phenotypes of these alleles are annotated with: rhabdomere; egg; adult brain.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: E1-like protein-activating enzyme Gsa7p/Apg7p; Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed during late larval stages, during early pupal stages.