Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Atg7
Flybase description The gene Autophagy-specific gene 7 is referred to in FlyBase by the symbol Dmel\Atg7 (CG5489, FBgn0034366).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.1502 -4.5833 -6.829976 -5.7616 -10.367352 -8.0758 -8.2583 -8.123337
    Affimetrix absolute value 6.765 5.43 5.407 5.867 5.387 5.563 5.521 5.255
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: catalytic activity; nucleotide binding.
There is experimental evidence that it is involved in the biological process: determination of adult lifespan; macroautophagy; regulation of defense response to virus; regulation of autophagy; autophagy; larval midgut cell programmed cell death.
11 alleles are reported.
The phenotypes of these alleles are annotated with: rhabdomere; egg; adult brain.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: E1-like protein-activating enzyme Gsa7p/Apg7p; Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed during late larval stages, during early pupal stages.