Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name rad50
Flybase description The gene rad50 is referred to in FlyBase by the symbol Dmel\rad50 (CG6339, FBgn0034728).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.7353 -2.7168 -5.393955 -2.8046 -8.805076 -4.1629 -3.90509 -6.999151
    Affimetrix absolute value 6.174 6.193 5.759 6.976 5.679 6.517 6.611 5.526
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: nuclease activity; zinc ion binding; ATP binding.
There is experimental evidence that it is involved in the biological process: instar larval development; response to DNA damage stimulus; telomere maintenance; chromosome organization; telomere capping.
6 alleles are reported.
The phenotypes of these alleles are annotated with: wing margin; eye; wing disc; chromosome, telomeric region; chaeta; condensed chromosome; wing.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Haemolysin E; Rad50 zinc hook; Recombination/repair protein Rad50; Zinc hook, Rad50.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 hour embryonic stages, in adult female stages.