Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CG11299
Flybase description The gene Sestrin is referred to in FlyBase by the symbol Dmel\Sesn (CG11299, FBgn0034897).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.2426 -1.6495 -2.609311 -2.7863 -3.111671 -2.8991 -1.31118 -3.055357
    Affimetrix absolute value 8.12 6.943 6.822 6.914 7.18 7.037 8.168 6.715
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Its molecular function is unknown.
There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; regulation of reactive oxygen species metabolic process; mitochondrion degradation; multicellular organismal aging; negative regulation of cell growth.
12 alleles are reported.
The phenotypes of these alleles are annotated with: Z disc; myofibril; actomyosin; wing blade; sarcomere; mitochondrion; M band.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: PA26 p53-induced protein (sestrin).
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed at stages throughout the pupal period.