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|Flybase description||The gene Epidermal growth factor receptor pathway substrate clone 15 is referred to in FlyBase by the symbol Dmel\Eps-15 (CG16932, FBgn0035060).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: calcium ion binding.
There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; synaptic vesicle endocytosis; vesicle-mediated transport; regulation of synaptic growth at neuromuscular junction.
22 alleles are reported.
The phenotypes of these alleles are annotated with: glial cell; eye disc; macrochaeta; bouton; embryonic/larval neuromuscular junction; socket.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand-like domain; EPS15 homology (EH).
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.