Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Trh
Flybase description The gene Tryptophan hydroxylase is referred to in FlyBase by the symbol Dmel\Trh (CG9122, FBgn0035187).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -46.5773 -24.9641 -28.35296 -39.2885 -48.397873 -35.6106 -48.15676 -27.442572
    Affimetrix absolute value 2.9 3.012 3.361 3.098 3.167 3.409 2.964 3.517
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: phenylalanine 4-monooxygenase activity; tryptophan 5-monooxygenase activity.
There is experimental evidence that it is involved in the biological process: regulation of circadian sleep/wake cycle, sleep; serotonin biosynthetic process.
5 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Aromatic amino acid hydroxylase; Aromatic amino acid hydroxylase, C-terminal; Aromatic amino acid hydroxylase, iron/copper binding site; Tryptophan 5-monooxygenase; Tyrosine 3-monooxygenase-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected.
Peak expression observed within 18-24 hour embryonic stages, during early larval stages.