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|Flybase description||The gene Peptidoglycan recognition protein LC is referred to in FlyBase by the symbol Dmel\PGRP-LC (CG4432, FBgn0035976).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: peptidoglycan receptor activity; protein binding; Gram-negative bacterial cell surface binding; protein dimerization activity; peptidoglycan binding.
There is experimental evidence that it is involved in the biological process: immune response; response to bacterium; positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; defense response to Gram-negative bacterium; positive regulation of antibacterial peptide biosynthetic process; antimicrobial humoral response; peptidoglycan recognition protein signaling pathway; defense response to virus; antibacterial humoral response.
37 alleles are reported.
No phenotypic data is available.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: N-acetylmuramoyl-L-alanine amidase domain; Peptidoglycan recognition protein; Peptidoglycan recognition protein family domain, metazoa/bacteria.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed during early pupal stages.