Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name TSG101
Flybase description The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, FBgn0036666).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.1429 1.8718 1.233429 1.6079 -0.659728 0.3299 -0.52296 0.230809
    Affimetrix absolute value 8.225 8.514 8.455 9.067 8.376 8.557 8.318 8.141
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: negative regulation of growth; negative regulation of growth of symbiont in host; regulation of JAK-STAT cascade; negative regulation of imaginal disc growth; maintenance of apical/basal cell polarity.
8 alleles are reported.
The phenotypes of these alleles are annotated with: yolk granule; oocyte; vesicle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Steadiness box; Tetratricopeptide-like helical; Ubiquitin E2 variant, N-terminal; Ubiquitin-conjugating enzyme/RWD-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed during late larval stages, at stages throughout the pupal period, in adult male stages.