Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CG7470
Flybase description This gene is referred to in FlyBase by the symbol Dmel\CG7470 (FBgn0037146).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -10.4212 6.2732 6.692506 1.2954 2.204862 2.3498 -3.13421 3.362771
    Affimetrix absolute value 5.055 10.264 10.911 8.753 9.893 9.779 7.027 9.959
    Affymetric present call in "x" number of chips 0 3 3 3 3 3 2 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: delta1-pyrroline-5-carboxylate synthetase activity; glutamate 5-kinase activity; glutamate-5-semialdehyde dehydrogenase activity.
Based on sequence similarity, it is predicted to be involved in the biological process: proline biosynthetic process.
2 alleles are reported.
No phenotypic data is available.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Aldehyde dehydrogenase domain; Aldehyde dehydrogenase, C-terminal; Aldehyde dehydrogenase, N-terminal; Aldehyde/histidinol dehydrogenase; Aspartate/glutamate/uridylate kinase; Delta l-pyrroline-5-carboxylate synthetase; Gamma-glutamyl phosphate reductase GPR; Gamma-glutamyl phosphate reductase GPR, conserved site; Glutamate 5-kinase, conserved site; Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase; Glutamate/acetylglutamate kinase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression.
Peak expression observed within 18-24 hour embryonic stages, in adult male stages.