Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name PEK
Flybase description The gene pancreatic eIF-2α kinase is referred to in FlyBase by the symbol Dmel\PEK (CG2087, FBgn0037327).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.7737 -1.2106 -2.533309 -2.7162 -5.465883 -2.8926 -4.47346 -4.088147
    Affimetrix absolute value 6.495 7.348 6.904 6.968 6.376 7.032 6.422 6.324
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: elongation factor-2 kinase activity.
There is experimental evidence that it is involved in the biological process: regulation of G2/M transition of mitotic cell cycle.
16 alleles are reported.
The phenotypes of these alleles are annotated with: eye disc; eye disc posterior to the morphogenetic furrow.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Pyrrolo-quinoline quinone beta-propeller repeat; Quinonprotein alcohol dehydrogenase-like; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.