Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name CG9461
Flybase description The gene FBX011 ortholog is referred to in FlyBase by the symbol Dmel\FBX011 (CG9461, FBgn0037760).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -8.749 -3.4449 -6.723706 -6.6977 -10.035773 -6.7819 -5.90731 -8.569218
    Affimetrix absolute value 5.28 5.836 5.47 5.677 5.454 5.803 6.0 5.173
    Affymetric present call in "x" number of chips 0 2 2 2 2 3 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: ubiquitin-protein ligase activity; zinc ion binding.
There is experimental evidence that it is involved in the biological process: regulation of gene silencing by RNA; siRNA loading onto RISC involved in chromatin silencing by small RNA.
8 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Carbohydrate-binding/sugar hydrolysis domain; F-box domain, Skp2-like; F-box domain, cyclin-like; Parallel beta-helix repeat; Parallel beta-helix repeat-2; Pectin lyase fold; Pectin lyase fold/virulence factor; Zinc finger, N-recognin.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.