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|Flybase description||The gene Sirt6 is referred to in FlyBase by the symbol Dmel\Sirt6 (CG6284, FBgn0037802).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; NAD+ binding.
There is experimental evidence that it is involved in the biological process: determination of adult lifespan.
3 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: NAD-dependent histone deacetylase, silent information regulator Sir2.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.