Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Sirt6
Flybase description The gene Sirt6 is referred to in FlyBase by the symbol Dmel\Sirt6 (CG6284, FBgn0037802).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -24.1806 -16.5158 -27.30446 -35.2456 -41.705676 -31.8692 -32.77283 -31.280077
    Affimetrix absolute value 3.818 3.586 3.426 3.265 3.378 3.574 3.523 3.303
    Affymetric present call in "x" number of chips 1 3 1 2 1 3 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; NAD+ binding.
There is experimental evidence that it is involved in the biological process: determination of adult lifespan.
3 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: NAD-dependent histone deacetylase, silent information regulator Sir2.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period.