Flygut: an atlas of the Drosophila adult midgut

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Gene name Gyc88E
Flybase description The gene Guanylyl cyclase at 88E is referred to in FlyBase by the symbol Dmel\Gyc88E (CG4154, FBgn0038295).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -37.2299 -23.5728 -32.616064 -39.4802 -45.365178 -46.34 -36.50421 -30.966222
    Affimetrix absolute value 3.196 3.125 3.234 3.102 3.262 3.032 3.367 3.373
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: guanylate cyclase activity; carbon monoxide binding; oxygen sensor activity; oxygen binding; heme binding; protein homodimerization activity; nitric oxide binding.
There is experimental evidence that it is involved in the biological process: response to hypoxia; cGMP biosynthetic process.
6 alleles are reported.
No phenotypic data is available.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Adenylyl cyclase class-3/4/guanylyl cyclase; Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site; Haem NO binding associated; Heme-NO binding; NO signalling/Golgi transport ligand-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression.
Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.