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|Flybase description||The gene Guanylyl cyclase at 88E is referred to in FlyBase by the symbol Dmel\Gyc88E (CG4154, FBgn0038295).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: guanylate cyclase activity; carbon monoxide binding; oxygen sensor activity; oxygen binding; heme binding; protein homodimerization activity; nitric oxide binding.
There is experimental evidence that it is involved in the biological process: response to hypoxia; cGMP biosynthetic process.
6 alleles are reported.
No phenotypic data is available.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Adenylyl cyclase class-3/4/guanylyl cyclase; Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site; Haem NO binding associated; Heme-NO binding; NO signalling/Golgi transport ligand-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression.
Peak expression observed within 12-24 hour embryonic stages, during early larval stages, during late pupal stages, in adult male stages.