Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Sirt2
Flybase description The gene Sirt2 is referred to in FlyBase by the symbol Dmel\Sirt2 (CG5085, FBgn0038788).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.6289 -1.3187 -1.925584 -2.4344 -2.928281 -2.96 -2.52023 -2.49792
    Affimetrix absolute value 7.707 7.225 7.239 7.108 7.217 6.998 7.219 6.953
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: NAD-dependent histone deacetylase activity.
There is experimental evidence that it is involved in the biological process: determination of adult lifespan; dendrite morphogenesis; protein deacetylation.
9 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: NAD-dependent deacetylase sirtuin-2, eukaryota; NAD-dependent histone deacetylase, silent information regulator Sir2.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 06-12 hour embryonic stages, at stages throughout the pupal period, in adult male stages.