Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name spas
Flybase description The gene spastin is referred to in FlyBase by the symbol Dmel\spas (CG5977, FBgn0039141).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -16.5617 -3.9573 -6.371 -7.2741 -12.684745 -7.2823 -6.77866 -9.225973
    Affimetrix absolute value 4.417 5.651 5.556 5.539 5.153 5.722 5.807 5.098
    Affymetric present call in "x" number of chips 2 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: ATPase activity.
There is experimental evidence that it is involved in the biological process: locomotory behavior; hemocyte migration; microtubule cytoskeleton organization; positive regulation of microtubule depolymerization.
28 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; organ system subdivision; peripheral nervous system; organelle; multicellular structure; intracellular non-membrane-bounded organelle; cell part; intracellular organelle part; intracellular organelle; cytoplasmic part; multidendritic neuron; adult segment.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, conserved site; ATPase, AAA-type, core; MIT.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages, during early pupal stages, in adult female stages.