Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name vav
Flybase description The gene vav is referred to in FlyBase by the symbol Dmel\vav (CG7893, FBgn0040068).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -9.7163 -4.0164 -10.054237 -7.3508 -16.941654 -11.1373 -9.59003 -14.272722
    Affimetrix absolute value 5.128 5.616 4.869 5.52 4.738 5.086 5.336 4.473
    Affymetric present call in "x" number of chips 3 3 2 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: guanyl-nucleotide exchange factor activity.
There is experimental evidence that it is involved in the biological process: regulation of cell shape; myoblast fusion; dorsal closure; axon guidance; cell adhesion; cell migration; actin filament organization; actin cytoskeleton reorganization; open tracheal system development.
8 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; longitudinal visceral muscle primordium; embryonic myoblast.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Calponin homology domain; Dbl homology (DH) domain; Pleckstrin homology domain; Pleckstrin homology-type; Protein kinase C-like, phorbol ester/diacylglycerol binding; SH2 motif; Src homology-3 domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.