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|Flybase description||The gene von Hippel-Lindau is referred to in FlyBase by the symbol Dmel\Vhl (CG13221, FBgn0041174).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; ubiquitin-protein ligase activity.
There is experimental evidence that it is involved in the biological process: negative regulation of microtubule depolymerization; establishment or maintenance of polarity of follicular epithelium; cytoskeleton organization; open tracheal system development; lumen formation, open tracheal system; epithelial cell migration, open tracheal system; protein ubiquitination.
12 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; late extended germ band embryo; non-connected developing system; tracheal branch primordium; portion of tissue; tracheal system; extended germ band embryo; dorsal trunk primordium; eo support cell; organelle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: von Hippel-Lindau disease tumor suppressor, beta domain; von Hippel-Lindau disease tumour suppressor, beta/alpha domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages.