Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Vhl
Flybase description The gene von Hippel-Lindau is referred to in FlyBase by the symbol Dmel\Vhl (CG13221, FBgn0041174).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.2963 -1.3235 -1.516811 -1.2155 -2.346083 -2.3651 -2.83656 -1.871175
    Affimetrix absolute value 8.769 7.234 7.577 8.118 7.539 7.331 7.096 7.339
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; ubiquitin-protein ligase activity.
There is experimental evidence that it is involved in the biological process: negative regulation of microtubule depolymerization; establishment or maintenance of polarity of follicular epithelium; cytoskeleton organization; open tracheal system development; lumen formation, open tracheal system; epithelial cell migration, open tracheal system; protein ubiquitination.
12 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; late extended germ band embryo; non-connected developing system; tracheal branch primordium; portion of tissue; tracheal system; extended germ band embryo; dorsal trunk primordium; eo support cell; organelle.
It has one annotated transcript and one annotated polypeptide.
Protein features are: von Hippel-Lindau disease tumor suppressor, beta domain; von Hippel-Lindau disease tumour suppressor, beta/alpha domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 06-12 hour embryonic stages.