Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name TepIV
Flybase description The gene Thiolester containing protein IV is referred to in FlyBase by the symbol Dmel\TepIV (CG10363, FBgn0041180).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.7243 1.2368 -1.291018 -0.6924 -1.568775 -0.6707 3.04428 -1.336727
    Affimetrix absolute value 9.188 7.89 7.852 7.986 8.167 8.181 10.043 7.87
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: peptidase inhibitor activity.
There is experimental evidence that it is involved in the biological process: antibacterial humoral response.
4 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: A-macroglobulin complement component; Alpha-2-macroglobulin; Alpha-2-macroglobulin, N-terminal; Alpha-2-macroglobulin, N-terminal 2; Alpha-2-macroglobulin, conserved site; Alpha-2-macroglobulin, thiol-ester bond-forming; Alpha-macroglobulin, receptor-binding; Terpenoid cylases/protein prenyltransferase alpha-alpha toroid.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, during early pupal stages.