Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name bin
Flybase description The gene biniou is referred to in FlyBase by the symbol Dmel\bin (CG18647, FBgn0045759).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -16.4958 -19.9844 -24.924765 -28.5504 -37.866499 -35.5349 -35.40296 -27.493748
    Affimetrix absolute value 4.375 3.322 3.555 3.554 3.522 3.417 3.406 3.523
    Affymetric present call in "x" number of chips 0 0 0 0 0 1 1 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding; sequence-specific enhancer binding RNA polymerase II transcription factor activity.
There is experimental evidence that it is involved in the biological process: mesodermal cell fate commitment; regulation of transcription from RNA polymerase II promoter; salivary gland morphogenesis.
9 alleles are reported.
The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; midgut constriction; embryonic somatic muscle; longitudinal visceral muscle primordium; visceral mesoderm derivative; circular visceral muscle primordium; embryonic pericardial cell.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Transcription factor, fork head; Transcription factor, fork head, conserved site; Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed at stages throughout embryogenesis.