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|Flybase description||The gene dumpy is referred to in FlyBase by the symbol Dmel\dp (CG33196, FBgn0053196).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: 4 iron, 4 sulfur cluster binding; serine-type endopeptidase inhibitor activity; endonuclease activity; calcium ion binding.
There is experimental evidence that it is involved in the biological process: apposition of dorsal and ventral imaginal disc-derived wing surfaces; chitin-based cuticle attachment to epithelium; lateral inhibition; open tracheal system development; chitin-based embryonic cuticle biosynthetic process.
312 alleles are reported.
The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system subdivision; adult segment; organ system; thoracic segment; late extended germ band embryo; non-connected developing system; adult; tracheal branch primordium; integumentary plate; eo support cell; adult trachea.
It has 12 annotated transcripts and 12 annotated polypeptides.
Protein features are: Cysteine-rich repeat; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Endonuclease III-like, iron-sulphur cluster loop motif; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Follistatin-like, N-terminal; Growth factor, receptor; Proteinase inhibitor I7, squash; Zona pellucida sperm-binding protein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.