Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name dp
Flybase description The gene dumpy is referred to in FlyBase by the symbol Dmel\dp (CG33196, FBgn0053196).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.696 -6.521 -21.306311 -19.6212 -44.04282 -26.1882 -0.42101 -18.213381
    Affimetrix absolute value 7.716 4.937 3.884 4.099 3.316 3.874 8.443 4.103
    Affymetric present call in "x" number of chips 3 3 0 2 0 1 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
An electronic pipeline based on InterPro domains suggests that it has the molecular function: 4 iron, 4 sulfur cluster binding; serine-type endopeptidase inhibitor activity; endonuclease activity; calcium ion binding.
There is experimental evidence that it is involved in the biological process: apposition of dorsal and ventral imaginal disc-derived wing surfaces; chitin-based cuticle attachment to epithelium; lateral inhibition; open tracheal system development; chitin-based embryonic cuticle biosynthetic process.
312 alleles are reported.
The phenotypes of these alleles are annotated with 21 unique terms, many of which group under: organ system subdivision; adult segment; organ system; thoracic segment; late extended germ band embryo; non-connected developing system; adult; tracheal branch primordium; integumentary plate; eo support cell; adult trachea.
It has 12 annotated transcripts and 12 annotated polypeptides.
Protein features are: Cysteine-rich repeat; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Endonuclease III-like, iron-sulphur cluster loop motif; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Follistatin-like, N-terminal; Growth factor, receptor; Proteinase inhibitor I7, squash; Zona pellucida sperm-binding protein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.