Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name As
Flybase description The gene Ubiquitin protein ligase E3A is referred to in FlyBase by the symbol Dmel\Ube3a (CG6190, FBgn0061469).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.8098 -2.5236 -2.868563 -3.9949 -4.983466 -4.2645 -7.14711 -4.734599
    Affimetrix absolute value 5.876 6.287 6.672 6.41 6.462 6.502 5.731 6.03
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 2 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity.
There is experimental evidence that it is involved in the biological process: locomotion; dendrite morphogenesis; circadian rhythm; long-term memory.
31 alleles are reported.
The phenotypes of these alleles are annotated with: wing margin; eye; retina; interommatidial bristle; dorsal multidendritic neuron ddaE; photoreceptor cell; dorsal multidendritic neuron ddaC; wing; dorsal multidendritic neuron ddaF; ommatidium.
It has one annotated transcript and one annotated polypeptide.
Protein features are: HECT; Ubiquitin-protein ligase E6-AP.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed during early pupal stages.