Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name pan
Flybase description The gene pangolin is referred to in FlyBase by the symbol Dmel\pan (CG34403, FBgn0085432).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -23.0891 -4.8468 -8.527452 -16.686 -22.36449 -12.8407 -11.77911 -15.982259
    Affimetrix absolute value 3.916 5.35 5.235 4.341 4.368 4.891 5.002 4.293
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: kinase binding; sequence-specific DNA binding; repressing transcription factor binding.
There is experimental evidence that it is involved in the biological process: regulation of Wnt receptor signaling pathway; regulation of stem cell proliferation; spiracle morphogenesis, open tracheal system; embryonic pattern specification; regulation of hemocyte differentiation; positive regulation of transcription, DNA-dependent; imaginal disc-derived wing morphogenesis; salivary gland morphogenesis.
44 alleles are reported.
The phenotypes of these alleles are annotated with 43 unique terms, many of which group under: organ system; organ system subdivision; adult segment; non-connected developing system; thoracic segment; late extended germ band embryo; portion of tissue; external compound sense organ; imaginal precursor; acellular anatomical structure.
It has 12 annotated transcripts and 12 annotated polypeptides.
Protein features are: CTNNB1 binding, N-teminal; High mobility group, HMG1/HMG2; High mobility group, superfamily.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.