Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name lap
Flybase description The gene like-AP180 is referred to in FlyBase by the symbol Dmel\lap (CG2520, FBgn0086372).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -45.7418 -17.3289 -34.062002 -36.3801 -54.38432 -39.2623 -37.2588 -39.22013
    Affimetrix absolute value 2.914 3.53 3.095 3.205 2.999 3.302 3.362 3.0
    Affymetric present call in "x" number of chips 1 3 1 2 0 2 3 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: 1-phosphatidylinositol binding; clathrin binding.
There is experimental evidence that it is involved in the biological process: phototaxis; synaptic transmission; neuron-neuron synaptic transmission; receptor-mediated endocytosis; synaptic vesicle endocytosis.
16 alleles are reported.
The phenotypes of these alleles are annotated with: eye; ommatidium; synaptic vesicle.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: ANTH; Clathrin adaptor, phosphoinositide-binding, GAT-like; ENTH/VHS; Epsin-like, N-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-06 and 12-24 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.