Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name ik2
Flybase description The gene IκB kinase-like 2 is referred to in FlyBase by the symbol Dmel\ik2 (CG2615, FBgn0086657).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -27.638 -20.744 -27.769941 -26.9713 -44.23041 -33.9098 -39.74893 -29.185881
    Affimetrix absolute value 3.649 3.26 3.389 3.64 3.296 3.498 3.302 3.406
    Affymetric present call in "x" number of chips 3 1 1 1 0 2 2 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: positive regulation of caspase activity; microtubule bundle formation; neuron remodeling; bristle morphogenesis; regulation of cytoskeleton organization; sensory organ precursor cell division; maintenance of epithelial integrity, open tracheal system; cell morphogenesis; actin filament organization; cell death.
28 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system subdivision; organ system; adult segment; external compound sense organ; cell part; eo support cell; organelle; humeral trabecule; late extended germ band embryo; integumentary plate.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult female stages.