Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name 5-HT2
Flybase description The gene Serotonin receptor 2 is referred to in FlyBase by the symbol Dmel\5-HT2 (CG1056, FBgn0087012).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -27.4845 -17.1567 -29.90319 -31.7953 -45.139541 -40.6904 -30.26785 -28.154533
    Affimetrix absolute value 3.631 3.519 3.303 3.399 3.286 3.215 3.647 3.452
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity.
There is experimental evidence that it is involved in the biological process: germ-band extension.
15 alleles are reported.
The phenotypes of these alleles are annotated with: gastrula embryo; extended germ band embryo; pole cell; embryonic epidermis; ventral midline; denticle belt.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed during late pupal stages.