Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Nedd4
Flybase description The gene Nedd4 is referred to in FlyBase by the symbol Dmel\Nedd4 (CG42279, FBgn0259174).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -6.1121 -2.8259 -4.048785 -2.6428 -5.197449 -3.8312 -3.92171 -4.332409
    Affimetrix absolute value 5.81 6.167 6.172 6.998 6.405 6.624 6.603 6.162
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Notch binding; protein binding; protein domain specific binding.
There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; receptor internalization; positive regulation of receptor internalization; axon guidance; positive regulation of synapse assembly; positive regulation of endocytosis; axon midline choice point recognition; protein ubiquitination.
45 alleles are reported.
The phenotypes of these alleles are annotated with: wing margin; wing vein L3; posterior commissure; wing margin bristle; anterior crossvein; longitudinal connective; presumptive embryonic/larval central nervous system; wing; wing vein; anterior commissure.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; C2 region; HECT; WW/Rsp5/WWP.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.