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|Flybase description||The gene Nedd4 is referred to in FlyBase by the symbol Dmel\Nedd4 (CG42279, FBgn0259174).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Notch binding; protein binding; protein domain specific binding.
There is experimental evidence that it is involved in the biological process: negative regulation of Notch signaling pathway; receptor internalization; positive regulation of receptor internalization; axon guidance; positive regulation of synapse assembly; positive regulation of endocytosis; axon midline choice point recognition; protein ubiquitination.
45 alleles are reported.
The phenotypes of these alleles are annotated with: wing margin; wing vein L3; posterior commissure; wing margin bristle; anterior crossvein; longitudinal connective; presumptive embryonic/larval central nervous system; wing; wing vein; anterior commissure.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; C2 region; HECT; WW/Rsp5/WWP.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.