Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Nop60B
Flybase description The gene Nucleolar protein at 60B is referred to in FlyBase by the symbol Dmel\Nop60B (CG3333, FBgn0259937).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -13.5581 -6.7976 -7.957312 -11.4456 -10.322776 -8.119 -16.02444 -10.841318
    Affimetrix absolute value 4.664 4.877 5.191 4.883 5.401 5.55 4.571 4.836
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 2 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: pseudouridylate synthase activity.
There is experimental evidence that it is involved in the biological process: wing disc development; ribosome biogenesis; germ cell development; rRNA processing; pseudouridine synthesis; neurogenesis.
21 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; adult segment; organ system subdivision; multicellular structure; thoracic segment; sense organ; eo support cell; adult; imaginal precursor; portion of tissue.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Dyskerin-like; PUA-like domain; Pseudouridine synthase II; Pseudouridine synthase, catalytic domain; Pseudouridine synthase-related; Pseudouridine synthase/archaeosine transglycosylase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, during early larval stages, in adult female stages.