Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name dl
Flybase description The gene dorsal is referred to in FlyBase by the symbol Dmel\dl (CG6667, FBgn0260632).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.4324 -2.0892 -5.96954 -4.8599 -10.81769 -4.9589 -3.49432 -5.120889
    Affimetrix absolute value 7.896 6.592 5.631 6.173 5.369 6.261 6.805 5.961
    Affymetric present call in "x" number of chips 3 3 2 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding; high mobility group box 1 binding; repressing transcription factor binding.
There is experimental evidence that it is involved in the biological process: immune response; melanization defense response; peripheral nervous system neuron development; maternal determination of anterior/posterior axis, embryo; regulation of hemocyte proliferation; regulation of alternative nuclear mRNA splicing, via spliceosome; plasmatocyte differentiation.
155 alleles are reported.
The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: organ system subdivision; organ system; adult segment; portion of tissue; multicellular structure; extended germ band embryo; imaginal precursor; epithelial furrow; spiracle; external compound sense organ.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Cell surface receptor IPT/TIG; Immunoglobulin E-set; Immunoglobulin-like fold; NF-kappa-B/Rel/dorsal; Rel homology; p53-like transcription factor, DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-06 and 18-24 hour embryonic stages.